If you’re exploring medical weight loss options, you’ve likely come across semaglutide (Wegovy®, Ozempic®) and tirzepatide (Zepbound™, Mounjaro™). These FDA-approved injectable medications are available at Youthology Medical Aesthetics and Wellness under the direction of board-certified physician Dr. Craig Grobman.
Both semaglutide and tirzepatide have shown significant weight loss results, but they also have some distinct differences. Understanding how they differ can help you decide which is best for your goals.
Semaglutide vs. Tirzepatide: How Do They Work?
Semaglutide is a GLP-1 receptor agonist that mimics the glucagon-like peptide-1 hormone. This action enhances insulin secretion, suppresses appetite, and slows the rate of gastric emptying. All these effects add up to reduced calorie intake and weight loss.
Tirzepatide is a dual GIP and GLP-1 receptor agonist. It targets both glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors. This dual mechanism increases insulin sensitivity and provides improved appetite suppression and metabolic benefits.
Efficacy: Which Leads to More Weight Loss?
Clinical studies have shown that tirzepatide may result in greater weight loss compared to semaglutide.
According to a 72-week study published by Diabetes, Obesity and Metabolism, participants taking tirzepatide lost an average of 17.8% of their body weight. Meanwhile, participants taking semaglutide in a similar timeframe lost about 12.4% of their body weight.
Why Would Someone Choose Semaglutide Over Tirzepatide?
Based on that information, tirzepatide might seem like the obvious choice. It’s not necessarily the most suitable weight loss solution for everyone, though.
Some people experience fewer gastrointestinal side effects with semaglutide, making it easier for them to use the medication consistently. Semaglutide has also been in use longer, a fact that gives some patients greater peace of mind.
Ultimately, no one medication works best for everyone. A consultation with a physician can help you make the right choice for your individual health needs and weight loss objectives.
Make the Right Decision for Your Weight Loss Goals
Are you ready to explore your options and learn more about semaglutide and tirzepatide? Contact Youthology Medical Aesthetics and Wellness at 516-817-6423 to schedule a consultation. Dr. Grobman and his team are here to support you as you work toward better health.
